exam 2.3
No description yet. This curated deck is ready for daily study.
Card preview (10)
In the [REDACTED], there are two strong forward pulling reactions. Which of the following is an enzyme from one of these reactions? Oxidative phase of PPP + TCA 2
Oxidation of glucose-6-phosphate by glucose 6-phosphate dehydrogenase Pull towards ribulose-5-phosphate by 6-phosphogluconate dehydrogenase is also strong (decarboxylation step) TCA: citrate synthase and isocitrate dehydrogenase
In the primary phase of the pentose phosphate shunt, there are reducing equivalents generated. Assuming, a [REDACTED] of glucose-6-phophate enters into the pentose phosphate shunt and is transformed to [REDACTED]. How many moles of which reducing equivalent are generated? 1mole of G6P Reduced to Ribulose-5-P
2 moles, NADPH
A patient presents with memory loss and partial paralysis. There is a syndrome with these symptoms. Metabolically speaking, what is the cause of this? 3
Wernicke-Korsakoff Syndrome. Transketolase loses its affinity to TPP (its cofactor) and Km increases resulting in fluctuation of Thiamine levels. Loss of affinity for a cofactor
The pentose phosphate shunt, phase 2, produces metabolites that are directly used in [REDACTED]?
glycolysis
Which enzyme in the pentose-phosphate-shunt can generate [REDACTED]? (Select all that apply) F6P NADPH – 2 ribose-5-phosphate
F6P– transketolase and transaldolase NADPH–glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (PGD) ribose 5-phosphate – transketolase
A patient presents with memory loss and partial paralysis. There is a syndrome with these symptoms. On a hunch, you order a metabolite index for pentose phosphate shunt metabolites. It seems like an enzyme is not running forward as fast as it should resulting in an increase of [REDACTED]. Which of the following is the most likely consequence? Increase of: Ribose-5-phosphate, xylulose-5-phosphate.
Increase in RU5P, S7P, G3P, F6P, G3P, E4P
Which of the following are products of Trans[REDACTED]ase? (Select all that apply) Transketolase 6 Transaldonase 4 ARE REVERSIBLE
Transketolase – Glyceraldehyde-3-phosphate, Sedoheptulose-7-phosphate, fructose 6-phosphate, erythrose 4 phosphate, xylulose 5 phosphate, ribose 5 phosphate. Transaldonase – fructose-6-phosphate and erythrose-4-phosphate (Forward), glyceraldehyde 3 phosphate and sedoheptulose 7 phosphate ( backwards. )
A patient presents with fatigue and metabolite analysis reveals elevated malate compared to normal samples. Based on this information, which enzyme is likely to be malfunctioning? 1
Citrate Synthase
Which TCA enzyme catalyzes the most [REDACTED]gonic reaction in the pathway? What is the rate limiting enzyme of [REDACTED]? exergonic endergonic step TCA cycle
exergonic→ Citrate Synthase Endergonic→ Malate Dehydrogenase TCA rate limiting enzyme is= isocitrate dehydrogenase
pathway