Week 3
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“angio”
vessel
Formation of new blood vessels enables
malignant tumor growth
diffusion-dependent tumor
Diffusion due to concentration gradients moves oxygen and nutrients towards tumor and moves wastes and carbon dioxide towards blood vessels
without blood supply, tumor size is limited to about:
1mm^3
Genetic mutations let some cancer cells secrete chemical signals
attract growing blood vessels
Metastasis name
indicates a changed state, not “static”
What kinds of cells normally move around inside your body?
White blood cells of various types, T-cells Macrophages Natural killer cells
cell movement looks like
crawling
what permits invasion?
Cell detachment and movement
what does metastasis require?
cells must enter blood vessels, survive, exit blood vessels and survive new location (rare)
Cellular definition of cancer:
A tumour is not a cancer, unless it has (or is likely to produce) cells able to detach, move, invade other tissues and spread throughout the body (metastasis)
metastasis
cells spreading throughout the body
occurrence of TAIM in animals
yes, yes, yes, yes
occurrence of TAIM in fungi
T - yes A - no? I - probably M - no
occurrence of TAIM in plants
T - yes A - yes … xylem, phloem I - cells could probably grow into it M - No, cells cannot detach and crawl (move)
occurrence of TAIM in prokaryotes
T - No – single cells can divide abnormally and clump, but there are no tissues A - No, single cells not multicellular I - No M - No
Cancer is only found among…
animals, multicellular eukaryotes (bilateria metazoans)
Cell walls of fungi and plant cells are
stiff and prevent cells moving around organism
galls
plant tumours form independently (no metastasis)
What did cancer originate in?
ancestors of multicellular animals (bilateria metazoans)
What is cancer?
Excess cell proliferation in a tissue Excess blood vessel formation Ability of some primary tumour cells to detach, move Secondary tumors form at distant locations
How are tumours classified
by place of origin and features
Where do carcinomas form
in epithelia
epithelia
All internal and external surfaces Body cavity surfaces Hollow organ surfaces Ducts and glands surfaces