Topic 18C: Organic synthesis
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What are grignard reagents, and what are they used for
molecules with a general formula of RMgX (R = alkyl group, X = halogen) used to lengthen the carbon chain of molecules
which conditions are needed to produce Grignard reagents
• dry ether • heat under reflux
write the chemical equation for the reaction between 1-chloro propane and magnsium
CH3CH2CH2Cl + Mg -> CH3CH2CH2MgCl
Describe the reaction between a Grignard reagent and carbon dioxide
• forms a product, which is then hydrolysed used a dilute acid (H3O^+) to form a carboxylic acid and halides
Write the chemical equation for the reaction between the Grignard reagent CH3CH2CH2MgBr and CO2
CH3CH2CH2MgBr + CO2 -> CH3CH2CH2COOMgBr CH3CH2CH2COOMgBr + H2O -> CH2CH2CH2COOH + Mg(OH)Br
Write the chemical equation for the reaction between the Grignard reagent CH3CH2CH2MgBr and RCOR’
CH3CH2CH2MgBr + RCOR’ -> CH3CH2CH2C(R)(R’)OMgBr CH3CH2CH2C(R)(R’)OMgBr + H2O -> CH3CH2CH2C(R)(R’)OH + Mg(OH)Br