Non-enzymatic Protein Function (5/15)

Shape and structure Motion Cell division Organelle and biomolecule transport

forms the microfilaments of the cytoskeleton and is very abundent

motion structure cell division muscle contraction

G-actin because they have a globular shape and posses a site where ATP or ADP can bind

It forms F-actin which stands are filamentous actin and two of these stick together to form a microfilament

when polymerization= depolymerization, we have tread-milling and when we want to stop, we have capping proteins

a long alpha-helical section very flexible: can be stretched

in the cytoplam

structural support cell adhesion organelle positioning

structural support for cilia and eukaryotic flagella chromosome separation during mitosis and meiosis intracellular transport

tubulin dimer consisting of an alpha-tubulin and a beta-tubulin bring GTP or GDP

transport motility muscle contraction

ATP-ases consumes energy from ATP hydrolysis

move to + end of microtubules which is to the periphery and this is called anterograde transport

heterotretramers made of of 4 subunits that are not all the same 2 subunits: heavy chains, with two head groups that are the feet 2 other subunits: light chains

ATP binds head to the microtubule causing a conformational change and swing with other head bound to ADP forward (ADP has head be detacted)

move to the cell center to the minus end and is called retrograde transport

found in cells with only cilia or flagellum

transport cargo for cell function

ATP-ases main job: muscle contraction

head, neck, and tail domains

selectins, cadherins, integrins

mediated inflammatory cells: platelets and endothelial cells

cytokines express selectins. luekocytes stick to selectins to slow them down and do reaction Heterophilic and Ca2+ dependent