PROSTATE CONDITIONS INCLUDING MEDICATIONS
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describe the hypothalamic pituitary testicular axis
hypothalamus releases GNRH ant pit releases FSH AND LH FSH BINDS TO SERTOLI CELLS (SUSTENTACULAR CELLS) TO NURTURE CELLS LH BINDS TO LEYDIG CELLS RESPONSIBLE FOR PRODUCTION OF sperm CELLS
WHAT IS THE ROLE OF SPERMATOGENIC CELLS
MAKE SPERM CELLS
WHAT IS THE ROLE OF SUSTENTACULAR (SERTOLI CELLS)
NOURISH DEVELOPING SPERM
WHAT IS THE ROLE OF INTERSITITIAL ENDOCHRINE CELLS (LEYDIG CELLS)
PRODUCE ANDROGENS > TESTOSTERONE
WHAT IS THE ROLE OF MYOID CELLS
CONTRACT RHYTHMICALLY TO SQUEEZE SPERM AND FLUIDS OUT ON THE SEMINEFEROUS TUBES
WHAT IS THE LOCATION OF THE PROSTATE
ENCIRCLES THE PROSTATIC URETHRA
THE PROSTATE IS MADE UP OF WHAT GLANDS
TUBULOALVEOLAR
WHAT ARE THE TUBULOALVEOLAR CELLS EMBEDDED IN
STROMA
THE SUPPORTS OF THE STROMA OF THE PROSTATE GLAND ARE
FIBROUS CT SMOOTH MM FIBRES PROSTATIC INTERSTIIAL CELLS
THE SMOOTH MUSCLE FIBRES OF THE STOMA OF TEH PROSTATE GLAND POSESS WHAT RECEPTORS
ALPHA 1 ANDRENERGIS RECEPTORS
WHAT DO ALPHA 1 ANDRONERGIC RECEPTORS RESPOND TO AND WHAT DOES IT CAUSE
SYMPATHETIC NS (NOREADRENALINE AND ADRENALINE) CAUSING PROSTATIC CONTRACTION
TAMSULOSIN IS WHAT KIND OF MEDICATION
ANDRONERGIC ANTAGONIST
what region of the sprostate is most commonly affected by benign prostatic hyperplaysia
transition zone
what causes benign prostatic hyperplaysia
DHT dihydrotestosterone
what region of the prostate is most commonly affected by prostate cancer
peripheral zone
what enzyme converts testosterone to DHT
5a reductatse
where does DHT bond and what does it do
androgen receptors in the prostate which stimulates production of growth factors
what are the two types of clinical features of benign prostatic hyperplaysia
obstructuve issues - obstruction to urinary flow irritative issues - retention of urine
where are 5a reductase receptors located
prostate and hair follicles
what drug unhibits 5 alpha reductase
finasteride
how does finasteride work
inhibits the 5 alpha reducatse receptors and in turn decreased the amount of Dihydrotestosterone in the prostate, causing less growth of the prostate. can also take to prevent male pattern baldness
what is the most common cancer of the prostate
adenocarcinoma
what is the aetiology of prostate cancer
unknown, but seems to be a complex interplay between age genetics, hormones, and environmental influences