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11. Pancreatic Function

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Total cards: 24•Content version: v4•Public deck•Updated: 8/1/2026

Card preview (24)

#1
Front (Question)

Major source of amylase?

Back (Answer)

Acinar cells of pancreas Salivary glands

#2
Front (Question)

What is required for functional activation of amylase

Back (Answer)

Calcium

#3
Front (Question)

What is required for FULL activation of amylase

Back (Answer)

Anions • bromide • chloride • cholate (coenzyme) • nitrate

#4
Front (Question)

2 coupled enzymatic rxns to measure amylase?

Back (Answer)

• NADH absorption - Free NP absorption (RXL method)

#5
Front (Question)

Why is heparin the only anticoagulant that can be used for amylase samples

Back (Answer)

Others chelate Ca2+ required for amylase’s functional activation

#6
Front (Question)

3 diseases that cause 05% of medical problems associated w/ pancreas?

Back (Answer)

• Acute pancreatitis • Chronic pancreatitis • Pancreatic carcinoma

#7
Front (Question)

Common causes of acute pancreatitis

Back (Answer)

• heavy alcohol use • intra-abdominal diseases (intestinal obstruction, gallstones blocking common bile duct) • infections, tumors, trauma

#8
Front (Question)

What happens to pancreatic ducts when there’s chronic pancreatitis

Back (Answer)

Pancreatic ducts calcified, scar tissue builds up = malabsorption

#9
Front (Question)

Common causes of chronic pancreatitis

Back (Answer)

• chronic alcohol abuse • autoimmune • genetic mutations due to CF • blocked pancreatic duct or common bile duct

#10
Front (Question)

What happens to AMY levels in chronic pancreatitis (initially, progress)

Back (Answer)

initially = elevated declines as acinar tissue destroyed

#11
Front (Question)

3 other disorders that can cause elevated AMY?

Back (Answer)

• Acute appendicitis • Salivary gland inflammation • Renal insufficiency

#12
Front (Question)

Reference method for lipase measurement?

Back (Answer)

Titrimetric

#13
Front (Question)

Serum and urine amylase levels in acute pancreatitis? (high/low)

Back (Answer)

Serum = high Urine = high

#14
Front (Question)

Serum and urine amylase levels in macroamylasemia? (High/low)

Back (Answer)

Serum = high Urine = low

#15
Front (Question)

What causes macroamylasemia

Back (Answer)

AMY binding to IgG and IgA = large macromolecule Can’t be filtered

#16
Front (Question)

Amylase: Creatinine Clearance Ratio (ACCR) is used to diagnose what?

Back (Answer)

Macroamylasemia

#17
Front (Question)

Almost all of the lipase found in serum is derived from the ________

Back (Answer)

pancreas

#18
Front (Question)

What do lipases hydrolyze?

Back (Answer)

Glycerol esters of triglycerides at ester bond to make glycerol + 3FA

#19
Front (Question)

Full activity of lipases requires..?

Back (Answer)

Cofactors - bile salts (sodium glycocholate) and colipase (coenzyme)

#20
Front (Question)

____ is effective in reducing lipase lag phase and activating it

Back (Answer)

Ca2+

#21
Front (Question)

5 rxn methods for analyzing lipase

Back (Answer)

• titrimetric • turbidimetric • spectrophotometric • fluorometric • immunological

#22
Front (Question)

Why would hemolysis falsely lower lipase results

Back (Answer)

Hgb inhibits activity of serum lipase

#23
Front (Question)

What can falsely increase lipase?

Back (Answer)

Drugs w/ high conc of free glycerol (colorimetric methods)

#24
Front (Question)

2 reasons why elevated lipase cause decrease calcium?

Back (Answer)

Release of free fatty acids from lipase activity => FAs bind to Ca2+ Liapse needs bile calcium salts as cofactors