PROTEIN

Synthesized in the liver and secreted by the hepatocyte into the circulation

The linear sequence of the amino acid Determines the identity of protein, molecular structure, function binding capacity and recognition ability

Refers to specific confirmations: alpha helix beta pleated sheets bend form

Actual 3-dimensional configuration Folding pattern of the protein Resposible for many of the physical and chemical properties of the proteins Maintained by electrovalent linkages, hydrogen bonds, disulfide bridges, Van der waals forces and hydrophobic interactions

Association of 2 or more polypeptide chains to form a functional protein molecule

What protein has no quaternary structure Consists of only a single polypeptide chain

Contain peptide chains which on hydrolysis yield only amino acids May be Fibrous or Globular in shape

Examples of Fibrous in shape

Example of Globular in shape

Composed of a protein and a non protein moiety (prosthetic group)

• Ferritin • Ceruloplasmin • Hemoglobin • Flavoproteins

VLDL HDL LDL Chylomicrons

Haptoglobin A1-Antitrypsin

Mucin Higher CHO content than CHON

Chromatin

Balance between anabolism (synthesis) and catabolism

When protein catabolism exceeds anabolism Excessive tissue destruction such as burns, wasting disease, high fever and starvation

When anabolism is greater than catabolism Ex: pregnancy, growth and repair processes

Migrates ahead of albumin Rich in tryptophan and contains 0.5% carbohydrate

Prealbumin is a transport protein for:

Prealbumin is used as a landmark to confirm that the specimen is really what

Other name of Prealbumin

Reference Value of Prealbumin

Prtein present in highest concentration in plasma