Regulation of Enzyme Activity
暂无描述。系统推荐的高质量记忆内容，适合每天坚持背诵学习。
卡片预览 (24 张)
What are metal ions to enzymes?
cofactors
What metal ion is located in the active site of carbonic anhydrase?
Zn2+
What is carbonic acids role in respiration?
.Binds to H2O, activating it for reaction with CO2 .Forms carbonic acid (H2CO3) .Dissociates into bicarbonate and a proton - reduces pH .Bicarbonate diffuses into blood
What is coenzymes function?
Carriers of reaction components
What does coenzyme A carry?
Acyl units
What do NAD(P)H and FAD(P)H2 carry?
electrons
What do biotin and thiamine pyrophosphate carry?
CO2 units bound to carboxylases
What is vitamin B3 also known as?
Niacin Nicotinic acid
What is NAD+?
Nicotinamide adenine dinucleotide (NAD+)
What is NADP+?
Nicotinamide adenine dinucleotide phosphate
What is pellagra?
Niacin/ tryptophan deficiency
What is the clinical presentation of pellagra?
Dementia, diarrhoea, dermatitis DDD
What is NAD+ role in alcohol metabolism?
Reduced to NADH, oxidises ethanol to acetaldehyde
What is needed to convert ethanol into acetaldehyde?
NAD+ and alcohol dehydrogenase
What part of the cell is ethanol converted to acetaldehyde?
Cytosol
What is G6PDH?
Glucose 6-phosphate dehydrogenase
What defects does G6PDH cause?
Metabolic defects
By what method is G6PDH deficiency inherited?
X-linked recessive
What does G6PDH make?
NADPH
What is NADPH needed for?
to drive biosynthesis of nucleic acids, lipids etc.
What are some symptoms of G6PDH deficiency?
Jaundice, haemolytic crisis
By what two pathways is glucose broken down?
Glycolysis Pentose phosphate pathway
What is made from the pentose phosphate pathway of glucose metabolism?
NADPH
What is needed to turn glucose 6-phosphate into 6-phosphoglucono-δ-lactone?
G6PDH6 NADP+ (converted into NADPH and H+)