16. Trace Elements, Atomic Absorption Spectrophotometry
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At what state can elements absorb radiation?
Ground state
Disease where copper is deficient and one where copper is in excess
Deficient - Menkes disease Excess - Wilsons disease
Increase of this compound in urine is highly suggestive of lead toxicity
Aminolevulinic acid (ALA)
Essential or non-essential? Antimony
Non-essential
Sample of choice for zinc analysis?
Plasma Not serum b/c zinc is 5-15% higher due to contamination from cells during clotting and spinning
Why is a morning specimen recommended for zinc analysis?
Concentrations of zinc are affected by circadian and postprandial fluctuations
What is acrodermatitis enteropathicia associated with?
Zinc deficiency
Toxin that can disrupt the production of heme
Lead
Essential or non-essential?Cobalt
Essential
Lipophilic form of mercury
Methylmercury
Lead poisoning may cause this to be seen in a peripheral blood film
Basophilic stippling
Essential or non-essential? Cadmium
Non-essential
Can cross BBB and placenta
Lead
Essential or non-essential? Molybdenum
Essential
This disease is diagnosed by green-gold Kayser-Fleischer rings in the cornea
Wilsons disease
Essential or non-essential? Aluminum
Non-essential
Mercury has a high affinity for ____________ in proteins
sulfhydryl groups
Trace element sample is held upright at room temperature for _____ mins to allow to clot
30 mins
Essential or non-essential? Selenium
Essential
Copper deficiency may be misdiagnosed as?
Myelodysplastic syndrome