Final Exam

Prions are made of _______.

Viroids only infect _______.

Prions cause _____.

(T/F) Prions invoke immune responses like viruses.

We discussed 5 kinds of human prion diseases. List them.

We discussed 4 animal prion diseases. List them.

Where did Kuru originate?

South Fore people practiced _________, a likely cause for the emergence of Kuru.

Kuru was originally known as _______ sickness.

In the 1950s, _______ traveled to New Guinea to study Kuru.

Gadjusek was the first to say that Kuru is _________.

What are the 3 stages of Kuru infection?

What is the length of the incubation period for Kuru?

_______ initiated research on Kuru, CJD, and Scrapie in 1972, later winning a Nobel prize for isolating a single infectious particle he named “prion”

Prion stands for?

What are the 2 forms of a prion?

In 1994, _______ used a yeast protein called ____ as a model organism for prion work, helping Pruisner’s work to be accepted.

(T/F) Prions are not very resistant to routine inactivation methods.

PrP is encoded by the ______ gene.

How does PrPres destroy neurons in the brain?

The misfolded protein structure of a prion has a high content of _____ _____.

How are more proteins misfolded after initial infection with a prion?

PrPc may bind to ______ and be shuttled into lysosomes where it is degraded.

Prions infect which 4 regions of the brain?