Lecture 01 and 02, Epithelia and CAMs/Junctional Complexes
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What are the two layers of the basement membrane
Basal Lamina and Reticular Lamina
What produces the Basal Lamina?
Epithelium
What produces the Reticular Lamina?
Connective Tissue
What are the 4 components of the Basal Lamina?
• Laminin 2. Type 4 Collagen 3. Entactin (nidogen) 4. Proteoglycans
What are the characteristics of Laminin
major component of the basal lamina made of 3 chains: Alpha, beta and gamma binding sites for integrins, type 4 collagen, enactin and proteoglycans (heparan sulfate)
What are the characteristics of Type 4 collagen
Does not form fibrils like type 1 Produced by epithelial cells, unlike type 1 collagen that is made by fibroblasts.
What are the characteristics of fibronectin?
binding sites along the laminin made of two polypeptide chains that are cross linked by DISULFIDE bonds
What are the forms of fibronectin?
Cellular- made by the fibroblasts, part of the extracellular matrix and Plasma- secreted into the blood stream by hepatocytes.
What are the binding sites on Fibronectin?
• Heparin (proteoglycan) 2. Integrins 3. Collagen 4. Fibrin
Which are the molecular complexes that primarily serve to prevent paracellular transport?
zonula occludens
Simple, non‐ciliated columnar epithelium is most like to be found associated with what?
Digestive tract. Note: different modifications to the apical domain happens along the GI tract, depending on the function.
Junctional complexes are associated with which cellular domains?
basolateral domain
Transitional epithelium is associated with which of the following?
Urinary bladder and parts of the ureters
The extracellular domains of which of the following bind to molecules in the extra cellular matrix such as fibronectin and laminin? A. Cadherins B. Integrins C. Selectins D. Immunoglobulin Superfamily
B. Integrins
Stratified cuboidal epithelium may be found where?
parts of the male urethra Also the anal mucosa and large excretory ducts of some glands
Lightly keratinized stratified squamous epithelium is characteristic of which location?
vaginal epithelium lining of mouth esophagus tongue and part of the epiglottis
Which of the following serve as a major interface between the cadherins that hold adjacent cells together and their actin cytoskeletons? A. Proteoglycans B. Catenins C. Laminins D. Keratins
C. Catenins
Which of the following are molecular complexes that anchor cells together and reinforce the physical integrity of tissues and the cells that make up the tissues?
zonula adherens
Which of the following types of cell adhesion molecules is associated with zonula occludens and desmosomes?
cadherins
Which of the following are only associated with the basal domains? A. zonula adherens B. zonla occludens C. Hemidesmosomes D. Desmosomes
hemidesmosomes, note: Integrins can be found on both the basal and the lateral domains
The basal lamina is associated with which type of collagen?
type IV
Desmocollins and desmogleins belong to which of the following groups of CAMs?
Cadherins
Which of the following are molecular complexes that primarily serve to prevent paracellular transport?
zona Occludens
Where can ciliated epithelia be found? Why is this particlar cell type found in those places?
Trachea, cilia promote the removal of irritants from the upper respiratory tract. Additionally, the ciliary elevator works to help the body dispose of trapped particles within the lungs. Oviduct: cilia helps to “wave” the ovum down the oviducts to the uterus