TOF MS
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What does TOF stand for in Time of Flight mass spectrometry?
Time of Flight
True or False: Time of Flight mass spectrometry is used to measure the mass-to-charge ratio of ions.
True
Fill in the blank: In TOF mass spectrometry, ions are accelerated by an _______.
electric field
What is the primary advantage of Time of Flight mass spectrometry?
High resolution and speed of analysis.
Which component of a TOF mass spectrometer is responsible for separating ions based on their flight times?
The flight tube
What is the purpose of the ion source in a TOF mass spectrometer?
To generate ions from the sample.
Fill in the blank: The time it takes for ions to travel through the flight tube is proportional to their _______.
mass-to-charge ratio
True or False: TOF mass spectrometry can analyze ions in the gas phase only.
True
Which factor affects the resolution of a TOF mass spectrometer?
The length of the flight tube.
What is one limitation of Time of Flight mass spectrometry?
It can struggle with very large molecules due to longer flight times.
Give two reasons samples must be ionised in TOF MS
So they can be accelerated by an electric field So ions create a current when they hit the detector and can be detected
Describe electrospray ionisation
Sample dissolved in a volatile solvent Injected through a capillary needle at high voltage Each molecule gains a proton