Exam 2
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What kind of genome does Hepatitis A have?
+ssRNA
What kind of genome does Hepatitis B have?
Partially dsDNA
What kind of genome does Hepatitis C have?
+ssRNA
Hepatitis A is a (naked/enveloped) virus
Naked
Hepatitis B is a (naked/enveloped) virus
Enveloped
Hepatitis C is a (naked/enveloped) virus
Enveloped
What family does Hepatitis A belong to?
Picornavirus
What family does Hepatitis B belong to?
Hepadnavirus
What family does Hepatitis C belong to?
Flavivirus
What is the mode of transmission for Hepatitis A?
Fecal-oral
What is the mode of transmission for Hepatitis B?
Blood, sexual contact
What is the mode of transmission for Hepatitis C?
Blood, sexual contact
Is there a vaccine available for Hepatitis A?
Yes!
Is there a vaccine available for Hepatitis B?
Yes!
Is there a vaccine available for Hepatitis C?
No!
In Hepatitis A, ___ is covalently linked to the 5’ end of the viral genome and a _____ is at the 3’ end.
VPg, polyA tail
Hepatitis A is cap (dependent/independent).
Independent
What feature of Hepatitis A allows for cap-independent translation of viral mRNA?
IRES sequence
Hepatitis A binds to ______ located on ______.
Mucin-like glycoprotein hepatitis A virus cellular receptor (huHAVcr-1), hepatocytes
(T/F) Hepatitis A synthesizes a polyprotein.
True
What is the protease encoded by Hepatitis A that cleaves the polyprotein?
Viral 3C
Viral 3D in Hepatitis A encodes _____________.
RNA-dependent RNA polymerase
What is the role of RNA-dependent RNA polymerase in Hepatitis A?
To synthesize –ssRNA and then genomic +ssRNA
(T/F) There is a specific treatment available for HAV infection.
False