Pathology
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Anatomic Pathologist
examines morphological (structural) changes in tissue and organs to examine cause of disease
Clinical physiologist
Examines change in blood (hematology and scrum chemistry) and tissue biopsy (cytology) to identify the cause of disease
Light Microscopy
Histology and Cytology -Common diagnostic technique -Light magnification to observe detailed tissue structure -Various stains are used (to help identify and differentiate tissue structure Resolution (ability to distinguish between two points): 200 um
Electron microscopy
-Improved resolution over the light microscope -Electron beam used to provide tissue details -Uncommon technique (older, not used for routine diagnostics) Revolution: 1-200 um
What are the three types of electron microscopy?
-transmission EM -scanning EM -Scanning-transmission
Immunohistochemistry
Antibody binds to antigen -Antibody is linked to a marker (fluorochloride of colour dye) – visualizing with microscope -Common diagnostic technique
Polymerase Chain Reaction (PCR)
Polymerase Chain Reaction (PCR) -Amplify segments of DNA: can amplify a single copy of DNA -Commonly identifies: infectious agents, tumor biomarkers, and other genetic material -Common diagnostic technique
Post Mortem examination (veterinary)
necropsy
Post Mortem examination (human)
Autopsy
What are the benefits of post-mortem analysis?
Common Cost effective Easy to perform (depends on skill of pathologist)
Paramixer virus (may be spelled wrong)
A virus that can transfer species (may be zoonotic) ex. Canine distemper
Pathos
Suffering or disease
Logos
Study of
Morbidity
diseased state
Mortality
Death
Pathology
They study of disease
Pathogenesis
The mechanism in which a sequence of events from a stimulus leads to a disease