Skin
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State the 5 layers of epidermis
Stratum Corneum Stratum Lucidum Stratum Granulosum Stratum Spinosum Stratum Basale
Describe stratum corneum (stratum lucidum)
30 day turnover Consists of protein keratin Desmosomes bind cells No cells or organelles present Disulphide linkages give strength Conversion of keratohyalin to keratin
Describe stratum granulosum
The presence of granules defines the layer Consist of granules of keratohyalin
Describe stratum spinosum
Spinous layer Preparative layer for keratinisation Created post-mortem: Cells shrink but desmosome junctions ‘create’ spines
Describe stratum basale (germinativum)
Continuous proliferation of stem cells to produce new keratinocytes Bound to other cells by desmosomes Bound to basement membrane by hemidesmosomes
The stratum basale is also known as the
Stratum germinativum
State the the 2 layers that make up the dermis
Papillary layer Reticular layer
State what the papillary layer is made up of
Loose connective tissue Blood vessels Nerve endings Macrophages irregular interface with epidermis
State what the reticular layer is made up of
Dense irregular connective tissue Collagen bundles in 3 planes Elastic fibres