Myogenesis
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How do somitic cells become committed to form muscle?
Expression of Pax3 and Pax7
What change occurs when myoblasts differentiate into myotubules?
They become bipolar in shape and fuse together to form multinucleate myotubules
What are the members of the Myogenic Regulatory Factors family?
MyoD MRF4 Myf5 Myogenin
What turns on the expression of the MRF family? And where are they expressed?
Pax3 Muscle precursors and muscle cells
Where is MRF4, MyoD and Myf5 expressed?
Proliferating, undifferentiated myogenic cells
Where is Myogenin expressed?
Non dividing, differentiated cells
What do the somites form?
1.Cartilage 2.Tendons 3.Skeletal muscle 5.Dermis (and vertebrae!)
What are the 2 myotome domains?
Epaxial (medial) Hypaxial (lateral)
What is required to generate myoblasts?
MyoD or or Myf5
What is required for muscle differentiation?
Myogenin
What do the mesenchymal cells of the limb bud secrete?
Hepatocyte growth factor/ scatter factor
What do the limb muscle progenitor cells express?
Pax3 induces the expression of the receptor c-met- binds to HGF/SF
What do satellite cells express when they differentiate?
MyoD and Myf5