LIPOPROTEINS
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enzymes that hydrolyzes TAG and CHOLE esters in lpp a. LPL b. hepatic lipase c. LCAT d. Endothelial lipase
Enzymes that participate in lpp metabolism Lipoprotein lipase (LPL) • hydrolyzes TAG and CHOLE esters in lpp • released of fatty acid and glycerol
enzymes that hydrolyzes TAG and phospholipids from HDL a. LPL b. hepatic lipase c. LCAT d. Endothelial lipase
Enzymes that participate in lpp mertabolism Hepatic phase • hydrolyzes TAG and phospholipids FROM HDL • hydrolyzes lipids ON VLDL and IDL Endothelial lipase -hydrolyzes TAG and phospholipids IN HDL
major end product from the catabolism of VLDL a. Chylomicron b. VLDL c. HDL d. LDL
LDL • major end product from the catabolism of VLDL • major source of cholesterol for tissues • most cholesterol rich of lipoprotein most atherogenic IDL • product of VLDL catabolism “VLDL REMNANT” • it is converted to LDL “ subclass of LDL”
subclass of LDL a. HDL b. Chylomicrons c. IDL d. Lp(a)
LDL • major end product from the catabolism of VLDL • major source of cholesterol for tissues • most cholesterol rich of lipoprotein most atherogenic IDL • product of VLDL catabolism “VLDL REMNANT” • it is converted to LDL “ subclass of LDL”
reverse cholesterol transport a. Chylomicron b. VLDL c. HDL d. LDL
HDL • it transports excess cholesterol from tissues and it to liver (REVERS CHOLESTEROL TRANSPORT) • HDL2 transports effectively the lipids to the liver and more cardioprotective
what is the CDC reference method for HDL a. liebermann burchardt b. abell kendal assay c. precipitation with heparin MnCl2 d. ultarcentrifugation
Hdl CDC reference method ultracentrifugation precipitation with heparin MnCl2 abell kendal assay (3 step method)
it is the primary target of cholesterol lowering therapy; PRIMARY MARKER FOR CHD RISK a. Chylomicron b. VLDL c. HDL d. LDL
LDL - PRIMARY MARKER FOR CHD RISK
increased level may indicate premature coronary heart disease and stroke a. IDL b. Lp (a) c. Beta- VLDL d. Lp X
Lp(a) / Lipoprotein A • knows as SINKING PRE-B LIPOPROTEIN • increased level may indicate PREMATURE CORONARY HEART DISEASE AND STROKE • independent risk factor for ATHEROSCLEROSIS
it is specific and sensitive indicator of cholestasis a. beta VLDL b. VLDL c. LDL d. Lpp X
Lipoprotein X • found in OBSTRUCTIVE JAUNDICE AND LCAT DEFICIENCY • SPECIFIC AND SENSITIVE INDICATOR OF CHOLESTASIS • Lipid content is mostly PHOSPHOLIPID AND FREE CHOLESTEROL • contains Apo C and Albumin
what abnormal lpp is rich in cholesterol than VLDL a. Lpp a b. Lpp X c. beta vldl d. IDL
Beta VLDL • abnormally migrating B-VLDL • RICH IN CHOLESTEROL THAN VDRL , due to catabolism of VLDL, there is failure to convert VLDL to LDL, causing IDL to accumulate also
sample collected using ______ is preferred sample a. edta b. sps c. serum separator tube d. heparin
sample collected using SERUM SEPARATOR TUBE is preferred sample