The Secretory Pathways
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What role do vesicles play in cellular transport?
Vesicles move along microtubules to other membranes and fuse with them within the cell.
Where are secreted proteins translated?
Secreted proteins are translated in ribosomes on the RER.
What are examples of secreted proteins?
• Peptide hormones • Digestive enzymes
What pathway do proteins follow after being synthesized in the RER?
The proteins move through the Golgi apparatus and are then packaged into secretory vesicles.
What happens to secretory vesicles after they are packaged?
These vesicles move to and fuse with the plasma membrane, releasing the proteins out of the cell.
Many secreted proteins are synthesized as _______ precursors.
inactive
What process is required for inactive precursors to become active proteins?
Proteolytic cleavage
What type of modification is proteolytic cleavage?
Post-translational modification
Which type of secreted proteins require proteolytic cleavage to become active?
Digestive enzymes